Forensic Scholars Today
Hypnotic medications, commonly known as sleeping pills, are the most common prescription
sleep aids in the U.S. Three closely related drugs (zolpidem/Ambien, zopiclone/Lunesta, and
zaleplon/Sonata) are often referred to as the “Z-drugs” because of their generic names. In addition to their
prescribed purposes, Z-drugs are sometimes used to facilitate crimes such as sexual-related offenses.
Therefore, the medical, forensic, and law enforcement communities must be aware of three key factors in
drug-facilitated sexual assaults.
Z-drugs are readily available, since they are generally safe and have fewer adverse effects than
other medications used historically as sleep aids. For example, older sleep aids like the barbiturates (e.g.,
secobarbital, amobarbital) were effective sleep aids but were often associated with fatal drug overdoses.
Although Z-drugs are generally safer than their previous therapeutic counterparts, widespread use has
made them available for drug diversion and illicit use.
Z-drugs amplify the effects of other central nervous depressants such as alcohol. In some
instances, Z-drugs have been placed into beverages with slight change in color or taste. This combined
effect can make an individual more susceptible to sexual assault and other criminal acts. Z-drugs have a
rapid onset of action and a relatively short duration of effect (less than eight hours). Defenseless, the
victim may awaken hours later with little or no memory of what happened.
Z-drugs are not detected by standard screening tests for drugs of abuse. Detection for Z-drugs in
urine or blood is problematic because at the present, no rapid laboratory tests exist. In fact, when Z-drugs
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are slipped into alcoholic beverages, routine testing often reveals only the presence of alcohol in the
blood or urine of the victim. This may lead to the conclusion that only the consumption of ethanol was
involved in the event. Detection of Z-drugs requires sophisticated analyses (e.g., gas
chromatography/mass spectrometry) available only at specialty clinics or forensic laboratories. The
difficulty to detect Z-drugs suggests that the incidence of crimes using Z-drugs is likely underestimated.
Matthew D. Krasowski, MD, PhD, is a pathologist and Director of Clinical Laboratories in the
Department of Pathology at the University of Iowa Hospitals and Clinics. He is interested in the
pharmacology and analytical toxicology of drugs of abuse. His published works include articles and book
chapters on pharmacology and drugs of abuse.
Jerrod Brown, M.A., M.S., M.S., M.S., is the Treatment Director for Pathways Counseling Center, Inc.
Pathways provides programs and services benefiting individuals impacted by mental illness and
addictions. Jerrod is also the founder and CEO of the American Institute for the Advancement of Forensic
Studies (AIAFS), and the lead developer and program director of an online graduate degree program in
Forensic Mental Health at Concordia University, St. Paul, Minnesota. Jerrod is currently pursuing his
doctoral degree in psychology.